Orexin-A vs Capromorelin
Head-to-head comparison of Orexin-A (Hypocretin-1 (Orexin-A)) and Capromorelin (Capromorelin hydrochloride) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Orexin-A | Capromorelin |
|---|---|---|
| Category | Cognitive Enhancement | Growth Hormone |
| Full Name | Hypocretin-1 (Orexin-A) | Capromorelin hydrochloride |
| Molecular Weight | 3562 Da | N/A |
| Half-Life | Minutes to <1 hour | about 2-3 hours |
| Amino Acids | 33 | N/A |
| Typical Dose | Research-only; no validated human dose | 0.25-2 mg/kg/day |
| Route | Intracerebroventricular/Intranasal | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 42 | 55 |
| Research Status | Pre-clinical | Clinical |
Orexin-A Benefits
- ✓wakefulness
- ✓attention
- ✓memory consolidation
- ✓fatigue resistance
Capromorelin Benefits
- ✓GH secretagogue activity
- ✓appetite stimulation
- ✓oral administration
- ✓translational animal model utility
Orexin-A Dosing
Research-only i.c.v. microgram/nanomolar studies|intranasal experimental use|no established human protocol
Capromorelin Dosing
0.25-2 mg/kg orally in studies|once-daily or protocol-specific dosing|monitor appetite and body weight
Orexin-A Side Effects
- ⚠insomnia
- ⚠headache
- ⚠blood pressure changes
Capromorelin Side Effects
- ⚠increased appetite
- ⚠vomiting or nausea
- ⚠lethargy
Research Overview
Orexin-A
Preclinical studies link orexin signaling to arousal, learning, and memory consolidation, making orexin-A a candidate for cognition-related research. It is not an approved cognitive enhancer and remains an experimental peptide.
Capromorelin
Research consistently shows capromorelin activates the ghrelin receptor pathway and increases food intake. Human development has been less prominent than veterinary use, but the compound remains a relevant GH secretagogue prototype.
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