Orexin-A vs Macimorelin
Head-to-head comparison of Orexin-A (Hypocretin-1 (Orexin-A)) and Macimorelin (Macimorelin acetate (AEZS-130)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Orexin-A | Macimorelin |
|---|---|---|
| Category | Cognitive Enhancement | Growth Hormone |
| Full Name | Hypocretin-1 (Orexin-A) | Macimorelin acetate (AEZS-130) |
| Molecular Weight | 3562 Da | N/A |
| Half-Life | Minutes to <1 hour | about 4-6 hours |
| Amino Acids | 33 | N/A |
| Typical Dose | Research-only; no validated human dose | 0.5 mg/kg single oral dose |
| Route | Intracerebroventricular/Intranasal | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 42 | 120 |
| Research Status | Pre-clinical | Clinical |
Orexin-A Benefits
- ✓wakefulness
- ✓attention
- ✓memory consolidation
- ✓fatigue resistance
Macimorelin Benefits
- ✓diagnostic GH stimulation
- ✓single oral dose
- ✓rapid measurable GH response
- ✓high clinical utility
Orexin-A Dosing
Research-only i.c.v. microgram/nanomolar studies|intranasal experimental use|no established human protocol
Macimorelin Dosing
0.5 mg/kg orally as a single dose|fasted testing conditions|serial GH sampling after administration
Orexin-A Side Effects
- ⚠insomnia
- ⚠headache
- ⚠blood pressure changes
Macimorelin Side Effects
- ⚠dysgeusia or taste disturbance
- ⚠nausea
- ⚠headache
Research Overview
Orexin-A
Preclinical studies link orexin signaling to arousal, learning, and memory consolidation, making orexin-A a candidate for cognition-related research. It is not an approved cognitive enhancer and remains an experimental peptide.
Macimorelin
Macimorelin has been validated in clinical testing as an oral alternative to injectable GH stimulation tests. Its short-term use makes it a useful translational tool for evaluating pituitary GH reserve.
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