Orexin-A vs hGHRH(1-37)OH
Head-to-head comparison of Orexin-A (Hypocretin-1 (Orexin-A)) and hGHRH(1-37)OH (Human growth hormone-releasing factor (1-37) hydroxyl) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Orexin-A | hGHRH(1-37)OH |
|---|---|---|
| Category | Cognitive Enhancement | Growth Hormone |
| Full Name | Hypocretin-1 (Orexin-A) | Human growth hormone-releasing factor (1-37) hydroxyl |
| Molecular Weight | 3562 Da | N/A |
| Half-Life | Minutes to <1 hour | 5-20 minutes |
| Amino Acids | 33 | 37 |
| Typical Dose | Research-only; no validated human dose | 1-2 mcg/kg |
| Route | Intracerebroventricular/Intranasal | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 42 | 60 |
| Research Status | Pre-clinical | Clinical Research |
Orexin-A Benefits
- ✓wakefulness
- ✓attention
- ✓memory consolidation
- ✓fatigue resistance
hGHRH(1-37)OH Benefits
- ✓GH release studies
- ✓minimal-sequence mapping
- ✓receptor pharmacology
- ✓peptide stability research
Orexin-A Dosing
Research-only i.c.v. microgram/nanomolar studies|intranasal experimental use|no established human protocol
hGHRH(1-37)OH Dosing
1-2 mcg/kg SC or IV bolus|acute stimulation with serial GH assays|short-course research administration with biomarker monitoring
Orexin-A Side Effects
- ⚠insomnia
- ⚠headache
- ⚠blood pressure changes
hGHRH(1-37)OH Side Effects
- ⚠flushing
- ⚠headache
- ⚠transient fatigue
Research Overview
Orexin-A
Preclinical studies link orexin signaling to arousal, learning, and memory consolidation, making orexin-A a candidate for cognition-related research. It is not an approved cognitive enhancer and remains an experimental peptide.
hGHRH(1-37)OH
Human GHRF(1-37)OH has appeared in studies examining how loss of C-terminal residues affects biological activity at the GHRH receptor. It is often used alongside other fragments to define structure-activity relationships within the GHRH family.
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