Omentin-1 vs Kisspeptin-54
Head-to-head comparison of Omentin-1 (Omentin-1 (Intelectin-1, ITLN1)) and Kisspeptin-54 (Kisspeptin-54 (metastin), 54-amino-acid KISS1 peptide fragment) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Omentin-1 | Kisspeptin-54 |
|---|---|---|
| Category | Diabetes & Metabolic | Sexual Health |
| Full Name | Omentin-1 (Intelectin-1, ITLN1) | Kisspeptin-54 (metastin), 54-amino-acid KISS1 peptide fragment |
| Molecular Weight | ~35 kDa | 5.9 kDa |
| Half-Life | hours | about 20-30 min |
| Amino Acids | 313 | 54 |
| Typical Dose | No approved human dose; research use only | 0.3-1.0 nmol/kg |
| Route | IV|SC | Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 82 | 110 |
| Research Status | Pre-clinical | Clinical |
Omentin-1 Benefits
- ✓insulin sensitivity
- ✓glucose uptake
- ✓lipid handling
Kisspeptin-54 Benefits
- ✓GnRH/LH stimulation
- ✓supports sex hormone signaling
- ✓may enhance sexual motivation
- ✓fertility-axis modulation
Omentin-1 Dosing
not established|not established
Kisspeptin-54 Dosing
0.3-1.0 nmol/kg IV bolus|single-dose experimental protocols|research-only endocrine monitoring
Omentin-1 Side Effects
- ⚠unknown
- ⚠immunogenicity risk
Kisspeptin-54 Side Effects
- ⚠flushing
- ⚠nausea
- ⚠headache
- ⚠hormonal shifts
Research Overview
Omentin-1
Lower omentin-1 levels are often associated with obesity, insulin resistance, and metabolic syndrome. Research continues on its use as a biomarker and as a mechanistic lead for AMPK-linked metabolic interventions.
Kisspeptin-54
Human studies show that kisspeptin-54 can acutely modulate reproductive neuroendocrine signaling, which makes it relevant to libido and sexual motivation research. Its effects are indirect compared with PT-141, but it is a well-established peptide in the scientific literature.
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