Neuropeptide S vs Hexarelin
Head-to-head comparison of Neuropeptide S (Neuropeptide S) and Hexarelin (Growth Hormone Releasing Hexapeptide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neuropeptide S | Hexarelin |
|---|---|---|
| Category | Cognitive Enhancement | Performance |
| Full Name | Neuropeptide S | Growth Hormone Releasing Hexapeptide |
| Molecular Weight | 2203 Da | 887.04 Da |
| Half-Life | Minutes to <1 hour | ~70 minutes |
| Amino Acids | 20 | 6 |
| Typical Dose | Research-only; no validated human dose | 100-200 mcg |
| Route | Intracerebroventricular/Intranasal | SC / IV |
| Purity | ≥98% | — |
| Studies Count | 28 | 198 |
| Research Status | Pre-clinical | Clinical Trials |
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
Hexarelin Benefits
- ✓Strongest GH pulse among GHRPs
- ✓Cardioprotective effects
- ✓Muscle mass and strength gains
- ✓Fat loss through improved body composition
- ✓Enhanced recovery from training
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
Hexarelin Dosing
Standard: 100-200 mcg SC 2-3 times daily|Pre-workout: 100 mcg 30 min before training|Pre-bed: 100 mcg for overnight GH pulse|Cycle: 8-12 weeks then 4 week break (desensitization)
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
Hexarelin Side Effects
- ⚠Common: Increased appetite, water retention, tingling
- ⚠Moderate: Cortisol and prolactin elevation (dose-dependent)
- ⚠Notable: Desensitization occurs after 4-16 weeks of continuous use
- ⚠Rare: Numbness in extremities
Research Overview
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
Hexarelin
Hexarelin has extensive pre-clinical and clinical evidence. Multiple human studies confirm potent GH release. Unique cardioprotective properties are well-documented. Note that receptor desensitization limits long-term continuous use.
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