Neuropeptide S vs GHRP-6
Head-to-head comparison of Neuropeptide S (Neuropeptide S) and GHRP-6 (Growth Hormone Releasing Peptide-6) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neuropeptide S | GHRP-6 |
|---|---|---|
| Category | Cognitive Enhancement | Performance |
| Full Name | Neuropeptide S | Growth Hormone Releasing Peptide-6 |
| Molecular Weight | 2203 Da | 873.01 Da |
| Half-Life | Minutes to <1 hour | ~15-60 minutes |
| Amino Acids | 20 | 6 |
| Typical Dose | Research-only; no validated human dose | 100-300 mcg |
| Route | Intracerebroventricular/Intranasal | SC / IV |
| Purity | ≥98% | — |
| Studies Count | 28 | 186 |
| Research Status | Pre-clinical | Clinical Trials |
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
GHRP-6 Benefits
- ✓Potent GH release stimulation
- ✓Muscle growth and strength
- ✓Appetite stimulation (ghrelin pathway)
- ✓Improved body composition
- ✓Enhanced recovery from training
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
GHRP-6 Dosing
Standard: 100-300 mcg SC 2-3 times daily|Pre-workout: 100 mcg 30 min before training|Pre-bed: 100-200 mcg for overnight GH pulse
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
GHRP-6 Side Effects
- ⚠Common: Increased appetite (significant), water retention, tingling
- ⚠Moderate: Cortisol elevation (dose-dependent), lethargy
- ⚠Rare: Elevated prolactin at high doses
Research Overview
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
GHRP-6
GHRP-6 has solid pre-clinical and clinical evidence for GH stimulation. Well-characterized pharmacology. More appetite stimulation than Ipamorelin due to ghrelin receptor activation.
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