Neuropeptide S vs IGF-1 LR3
Head-to-head comparison of Neuropeptide S (Neuropeptide S) and IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neuropeptide S | IGF-1 LR3 |
|---|---|---|
| Category | Cognitive Enhancement | Performance |
| Full Name | Neuropeptide S | Insulin-like Growth Factor-1 Long R3 |
| Molecular Weight | 2203 Da | 9,117 Da |
| Half-Life | Minutes to <1 hour | ~20-30 hours |
| Amino Acids | 20 | 83 |
| Typical Dose | Research-only; no validated human dose | 20-100 mcg |
| Route | Intracerebroventricular/Intranasal | IM / SC |
| Purity | ≥98% | — |
| Studies Count | 28 | 298 |
| Research Status | Pre-clinical | Pre-clinical |
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
IGF-1 LR3 Benefits
- ✓Promotes muscle hyperplasia (new muscle cells)
- ✓Extended half-life vs native IGF-1
- ✓Enhanced protein synthesis
- ✓Improved nutrient partitioning
- ✓Anti-catabolic effects
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
IGF-1 LR3 Dosing
Standard: 20-50 mcg IM post-workout|Advanced: 50-100 mcg IM or SC daily|Cycle: 4-6 weeks on, 4 weeks off
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
IGF-1 LR3 Side Effects
- ⚠Common: Hypoglycemia (dose-dependent), joint pain, water retention
- ⚠Moderate: Gut growth concern (high doses), acromegaly-like symptoms
- ⚠Serious: Theoretical cancer risk (prolonged high-dose use)
Research Overview
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
IGF-1 LR3
IGF-1 LR3 has extensive in vitro and animal data. Its role in muscle hyperplasia is well-documented. The extended half-life modification provides practical advantages over native IGF-1.
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