Neuropeptide S vs hGHRH(1-37)OH
Head-to-head comparison of Neuropeptide S (Neuropeptide S) and hGHRH(1-37)OH (Human growth hormone-releasing factor (1-37) hydroxyl) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neuropeptide S | hGHRH(1-37)OH |
|---|---|---|
| Category | Cognitive Enhancement | Growth Hormone |
| Full Name | Neuropeptide S | Human growth hormone-releasing factor (1-37) hydroxyl |
| Molecular Weight | 2203 Da | N/A |
| Half-Life | Minutes to <1 hour | 5-20 minutes |
| Amino Acids | 20 | 37 |
| Typical Dose | Research-only; no validated human dose | 1-2 mcg/kg |
| Route | Intracerebroventricular/Intranasal | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 28 | 60 |
| Research Status | Pre-clinical | Clinical Research |
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
hGHRH(1-37)OH Benefits
- ✓GH release studies
- ✓minimal-sequence mapping
- ✓receptor pharmacology
- ✓peptide stability research
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
hGHRH(1-37)OH Dosing
1-2 mcg/kg SC or IV bolus|acute stimulation with serial GH assays|short-course research administration with biomarker monitoring
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
hGHRH(1-37)OH Side Effects
- ⚠flushing
- ⚠headache
- ⚠transient fatigue
Research Overview
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
hGHRH(1-37)OH
Human GHRF(1-37)OH has appeared in studies examining how loss of C-terminal residues affects biological activity at the GHRH receptor. It is often used alongside other fragments to define structure-activity relationships within the GHRH family.
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