Neuropeptide S vs Anamorelin
Head-to-head comparison of Neuropeptide S (Neuropeptide S) and Anamorelin (Anamorelin hydrochloride (ONO-7643)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neuropeptide S | Anamorelin |
|---|---|---|
| Category | Cognitive Enhancement | Growth Hormone |
| Full Name | Neuropeptide S | Anamorelin hydrochloride (ONO-7643) |
| Molecular Weight | 2203 Da | N/A |
| Half-Life | Minutes to <1 hour | about 9 hours |
| Amino Acids | 20 | N/A |
| Typical Dose | Research-only; no validated human dose | 50 mg/day |
| Route | Intracerebroventricular/Intranasal | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 28 | 95 |
| Research Status | Pre-clinical | Clinical |
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
Anamorelin Benefits
- ✓stimulates appetite
- ✓raises IGF-1
- ✓may support weight gain
- ✓oral dosing
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
Anamorelin Dosing
50 mg orally once daily|often studied with food or per protocol|track weight, appetite, and glucose markers
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
Anamorelin Side Effects
- ⚠hyperglycemia
- ⚠peripheral edema
- ⚠constipation or nausea
Research Overview
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
Anamorelin
Trials in cachexia populations showed increased appetite and modest gains in body weight and IGF-1. Regulatory progress has varied by region, but it remains a well-studied ghrelin agonist in the GH space.
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