MK-677 vs Tianeptine sodium
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and Tianeptine sodium (Tianeptine sodium) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | MK-677 | Tianeptine sodium |
|---|---|---|
| Category | Growth Hormone | Cognitive Enhancement |
| Full Name | Ibutamoren Mesylate (MK-677) | Tianeptine sodium |
| Molecular Weight | 528.662 g/mol | 458.94 Da |
| Half-Life | ~24 hours | About 2.5 hours |
| Amino Acids | Non-peptide compound | N/A |
| Typical Dose | — | 12.5 mg 3 times daily |
| Route | — | Oral |
| Purity | >99% | ≥98% |
| Studies Count | 120 | 280 |
| Research Status | Active Research | Clinical |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
Tianeptine sodium Benefits
- ✓mood improvement
- ✓anxiety reduction
- ✓cognitive clarity
- ✓stress adaptation
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
Tianeptine sodium Dosing
12.5 mg oral 3x/day|25 mg/day oral|clinical antidepressant dosing
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
Tianeptine sodium Side Effects
- ⚠nausea
- ⚠dizziness
- ⚠dependence risk
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
Tianeptine sodium
Clinical studies support tianeptine as an antidepressant with a distinctive glutamatergic and neuroplasticity-related profile. Some evidence suggests cognitive benefits in mood-impaired populations, likely secondary to improved stress handling and affect.
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