MK-677 vs Omentin-1
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and Omentin-1 (Omentin-1 (Intelectin-1, ITLN1)) — benefits, dosing, side effects, research data, and where to buy.
| Property | MK-677 | Omentin-1 |
|---|---|---|
| Category | Growth Hormone | Diabetes & Metabolic |
| Full Name | Ibutamoren Mesylate (MK-677) | Omentin-1 (Intelectin-1, ITLN1) |
| Molecular Weight | 528.662 g/mol | ~35 kDa |
| Half-Life | ~24 hours | hours |
| Amino Acids | Non-peptide compound | 313 |
| Typical Dose | — | No approved human dose; research use only |
| Route | — | IV|SC |
| Purity | >99% | ≥98% |
| Studies Count | 120 | 82 |
| Research Status | Active Research | Pre-clinical |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
Omentin-1 Benefits
- ✓insulin sensitivity
- ✓glucose uptake
- ✓lipid handling
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
Omentin-1 Dosing
not established|not established
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
Omentin-1 Side Effects
- ⚠unknown
- ⚠immunogenicity risk
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
Omentin-1
Lower omentin-1 levels are often associated with obesity, insulin resistance, and metabolic syndrome. Research continues on its use as a biomarker and as a mechanistic lead for AMPK-linked metabolic interventions.
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