MK-677 vs Histatin-5
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and Histatin-5 (Human histatin 5) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | MK-677 | Histatin-5 |
|---|---|---|
| Category | Growth Hormone | Dental & Oral |
| Full Name | Ibutamoren Mesylate (MK-677) | Human histatin 5 |
| Molecular Weight | 528.662 g/mol | 3035 Da |
| Half-Life | ~24 hours | minutes in saliva |
| Amino Acids | Non-peptide compound | 24 |
| Typical Dose | — | 1-100 µM in research formulations |
| Route | — | Topical/Oral rinse |
| Purity | >99% | ≥98% |
| Studies Count | 120 | 120 |
| Research Status | Active Research | Pre-clinical |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
Histatin-5 Benefits
- ✓anti-Candida activity
- ✓biofilm suppression
- ✓mucosal wound support
- ✓oral innate immunity
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
Histatin-5 Dosing
topical rinse or gel|short contact exposure|repeat applications in research protocols
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
Histatin-5 Side Effects
- ⚠local irritation
- ⚠proteolytic instability
- ⚠dose-dependent cytotoxicity in vitro
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
Histatin-5
Histatin-5 is a major salivary defense peptide that can kill Candida species and influence oral microbial communities. It is also investigated for wound-healing and xerostomia-associated oral infection models.
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