MK-677 vs Arginine Vasopressin
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and Arginine Vasopressin (8-Arginine Vasopressin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | MK-677 | Arginine Vasopressin |
|---|---|---|
| Category | Growth Hormone | Cognitive Enhancement |
| Full Name | Ibutamoren Mesylate (MK-677) | 8-Arginine Vasopressin |
| Molecular Weight | 528.662 g/mol | 1084.23 Da |
| Half-Life | ~24 hours | 10-20 minutes |
| Amino Acids | Non-peptide compound | 9 |
| Typical Dose | — | 10-40 IU intranasal research range |
| Route | — | Intranasal/Subcutaneous |
| Purity | >99% | ≥98% |
| Studies Count | 120 | 100 |
| Research Status | Active Research | Clinical |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
Arginine Vasopressin Benefits
- ✓memory consolidation
- ✓recall support
- ✓arousal-linked learning
- ✓social cognition
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
Arginine Vasopressin Dosing
intranasal research dosing|10-40 IU per dose in studies|single or repeated administration
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
Arginine Vasopressin Side Effects
- ⚠blood pressure elevation
- ⚠headache
- ⚠hyponatremia
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
Arginine Vasopressin
Animal and human studies indicate vasopressin can modulate hippocampal and limbic circuits involved in learning and memory. The effect size is context dependent, and results vary by dose, route, and baseline cognitive state.
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