Methoxy PEG-Epoetin Beta vs ACE-031
Head-to-head comparison of Methoxy PEG-Epoetin Beta (Methoxy polyethylene glycol-epoetin beta (CERA)) and ACE-031 (ACE-031 (soluble activin receptor type IIB-Fc)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Methoxy PEG-Epoetin Beta | ACE-031 |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | Methoxy polyethylene glycol-epoetin beta (CERA) | ACE-031 (soluble activin receptor type IIB-Fc) |
| Molecular Weight | ≈60,000 Da | ~95 kDa |
| Half-Life | ~130 h | Days to weeks |
| Amino Acids | 165 | N/A |
| Typical Dose | 0.6 mcg/kg SC every 2 weeks or 1.2 mcg/kg SC monthly | 0.1-3 mg/kg in early studies |
| Route | Subcutaneous/IV | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 95 | 75 |
| Research Status | Clinical | Clinical |
Methoxy PEG-Epoetin Beta Benefits
- ✓long-acting erythropoiesis
- ✓stable hemoglobin
- ✓fewer injections
- ✓improved oxygen delivery
ACE-031 Benefits
- ✓myostatin/activin neutralization
- ✓lean mass gain
- ✓muscle function support
- ✓anti-catabolic effect
Methoxy PEG-Epoetin Beta Dosing
0.6 mcg/kg SC every 2 weeks|1.2 mcg/kg SC monthly|Adjust based on hemoglobin
ACE-031 Dosing
Clinical studies used single or repeated SC doses|dose escalation in mg/kg|monitoring for edema/bleeding
Methoxy PEG-Epoetin Beta Side Effects
- ⚠hypertension
- ⚠thromboembolism
- ⚠headache
ACE-031 Side Effects
- ⚠telangiectasia/vascular effects
- ⚠epistaxis
- ⚠headache/edema
Research Overview
Methoxy PEG-Epoetin Beta
Clinical trials show predictable hemoglobin correction with a long dosing interval and sustained red-cell stimulation. Any VO2 max effect would be secondary to higher hemoglobin, not a direct ergogenic mechanism.
ACE-031
ACE-031 produced increases in lean mass in early studies, but development was curtailed after safety concerns and variable efficacy. Its literature remains important because it validated activin receptor blockade as a muscle-building strategy.
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