Kahalalide F vs SNX-482
Head-to-head comparison of Kahalalide F (Kahalalide F) and SNX-482 (SNX-482 peptide from Hysterocrates gigas venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Kahalalide F | SNX-482 |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Kahalalide F | SNX-482 peptide from Hysterocrates gigas venom |
| Molecular Weight | 1111.3 Da | 4,300 Da |
| Half-Life | N/A | Minutes to hours |
| Amino Acids | N/A | 41 |
| Typical Dose | 0.1-3 mg/m2 IV in early trials | 0.01-1 nmol intrathecal|1-100 nM in vitro|single-dose electrophysiology studies |
| Route | Intravenous | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 85 | 85 |
| Research Status | Pre-clinical | Pre-clinical |
Kahalalide F Benefits
- ✓antineoplastic
- ✓pro-apoptotic
- ✓membrane-active
- ✓anti-proliferative
SNX-482 Benefits
- ✓Cav2.3 blockade
- ✓synaptic transmission studies
- ✓excitability mapping
- ✓pain and epilepsy research
Kahalalide F Dosing
IV infusion in phase I oncology studies|dose escalation used in trials|preclinical nanomolar assays
SNX-482 Dosing
Patch-clamp Cav2.3 assays|Intrathecal neurophysiology studies|Acute channel-blockade experiments
Kahalalide F Side Effects
- ⚠fatigue
- ⚠nausea
- ⚠transaminase elevation
SNX-482 Side Effects
- ⚠Ataxia at high exposure
- ⚠off-target calcium-channel block
- ⚠cardiovascular effects in animal models
Research Overview
Kahalalide F
Kahalalide F was investigated in multiple preclinical and early clinical cancer studies because of its unusual membrane-disrupting and anti-tumor effects. Development highlighted the promise and limits of marine depsipeptides as oncology leads.
SNX-482
SNX-482 has been used to dissect R-type calcium currents in neurons and endocrine cells, and to map the role of Cav2.3 in excitability. Its selectivity profile has made it a standard research reagent in channel pharmacology.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.