IGF-1 DES vs 5-Amino-1MQ
Head-to-head comparison of IGF-1 DES (Des(1-3) Insulin-like Growth Factor 1) and 5-Amino-1MQ (5-Amino-1-methylquinolinium) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | IGF-1 DES | 5-Amino-1MQ |
|---|---|---|
| Category | Growth Hormone | Weight Management |
| Full Name | Des(1-3) Insulin-like Growth Factor 1 | 5-Amino-1-methylquinolinium |
| Molecular Weight | 7365 Da | 178.23 g/mol |
| Half-Life | ~20-30 minutes | ~6 hours |
| Amino Acids | 67 | Small molecule |
| Typical Dose | — | — |
| Route | — | — |
| Purity | >98% | >98% |
| Studies Count | 65 | 28 |
| Research Status | Active Research | Active Research |
IGF-1 DES Benefits
- ✓Highly potent localized muscle growth, enhanced protein synthesis, satellite cell proliferation, does not bind to IGFBPs, rapid onset
5-Amino-1MQ Benefits
- ✓Reduces body fat without appetite changes, lowers cholesterol, increases NAD+ levels, improves metabolic efficiency, supports cellular energy production
IGF-1 DES Dosing
50-150 mcg per injection site bilaterally post-workout. 4-6 week cycles due to potency. Multiple daily injections in research.
5-Amino-1MQ Dosing
Research doses: 50-150 mg orally daily. Often cycled 8-12 weeks on, 4 weeks off. Best taken in the morning.
IGF-1 DES Side Effects
- ⚠Hypoglycemia (dose-dependent), localized swelling, shorter duration limits systemic exposure compared to IGF-1 LR3.
5-Amino-1MQ Side Effects
- ⚠Generally well-tolerated in preclinical models. Potential mild GI discomfort and headache. Long-term human safety data is limited.
Research Overview
IGF-1 DES
Missing first three amino acids (Gly-Pro-Glu) eliminates IGFBP binding, resulting in 100% bioavailable IGF-1R stimulation. Activates PI3K/Akt/mTOR for protein synthesis and satellite cell proliferation.
5-Amino-1MQ
Studies in diet-induced obese mice showed significant reductions in body weight, white adipose tissue mass, and cholesterol levels without changes in food intake. Works by inhibiting NNMT enzyme to increase NAD+ and activate sirtuins.
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