Histatin-5 vs Larazotide
Head-to-head comparison of Histatin-5 (Human histatin 5) and Larazotide (Larazotide acetate (AT-1001)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Histatin-5 | Larazotide |
|---|---|---|
| Category | Dental & Oral | Gastrointestinal |
| Full Name | Human histatin 5 | Larazotide acetate (AT-1001) |
| Molecular Weight | 3035 Da | N/A |
| Half-Life | minutes in saliva | short; designed for local gut action |
| Amino Acids | 24 | 8 |
| Typical Dose | 1-100 µM in research formulations | 0.5-4 mg TID (clinical studies) |
| Route | Topical/Oral rinse | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 40 |
| Research Status | Pre-clinical | Clinical |
Histatin-5 Benefits
- ✓anti-Candida activity
- ✓biofilm suppression
- ✓mucosal wound support
- ✓oral innate immunity
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
Histatin-5 Dosing
topical rinse or gel|short contact exposure|repeat applications in research protocols
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
Histatin-5 Side Effects
- ⚠local irritation
- ⚠proteolytic instability
- ⚠dose-dependent cytotoxicity in vitro
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
Research Overview
Histatin-5
Histatin-5 is a major salivary defense peptide that can kill Candida species and influence oral microbial communities. It is also investigated for wound-healing and xerostomia-associated oral infection models.
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
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