HGH Fragment 176-191 vs AICAR
Head-to-head comparison of HGH Fragment 176-191 (Human Growth Hormone Fragment 176-191) and AICAR (5-Aminoimidazole-4-carboxamide Ribonucleotide (Acadesine)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | HGH Fragment 176-191 | AICAR |
|---|---|---|
| Category | Weight Management | Performance |
| Full Name | Human Growth Hormone Fragment 176-191 | 5-Aminoimidazole-4-carboxamide Ribonucleotide (Acadesine) |
| Molecular Weight | 1817.12 g/mol | 338.21 g/mol |
| Half-Life | ~30 minutes | ~2-3 hours |
| Amino Acids | 16 | Nucleoside analog |
| Typical Dose | — | — |
| Route | — | — |
| Purity | >98% | >99% |
| Studies Count | 45 | 180 |
| Research Status | Active Research | Active Research |
HGH Fragment 176-191 Benefits
- ✓Targeted fat loss, no blood sugar impact, no IGF-1 elevation, inhibits lipogenesis, stimulates lipolysis, improved body composition
AICAR Benefits
- ✓Increases endurance capacity, enhances fatty acid oxidation, promotes mitochondrial biogenesis, improves glucose uptake, cardioprotective effects
HGH Fragment 176-191 Dosing
250-500 mcg subcutaneously 1-2 times daily on empty stomach. 12-16 week cycles typical in research.
AICAR Dosing
Research doses: 50-150 mg subcutaneously. Typically administered 30-60 minutes before physical activity in research settings.
HGH Fragment 176-191 Side Effects
- ⚠Injection site irritation, headache, drowsiness. Does not affect blood sugar, insulin sensitivity, or elevate IGF-1.
AICAR Side Effects
- ⚠Potential hypoglycemia, lactic acidosis at high doses, injection site reactions. Banned by WADA as a metabolic modulator.
Research Overview
HGH Fragment 176-191
This 16-amino-acid fragment specifically targets adipose tissue via beta-3 adrenergic receptors. Works through a GH-receptor-independent pathway, explaining selective fat-loss properties without growth-promoting effects.
AICAR
Salk Institute researchers demonstrated AICAR could increase endurance in sedentary mice by 44% without exercise training. Activates AMPK, triggering PGC-1α expression, mitochondrial biogenesis, and enhanced fatty acid β-oxidation.
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