AICAR vs DSIP
Head-to-head comparison of AICAR (5-Aminoimidazole-4-carboxamide Ribonucleotide (Acadesine)) and DSIP (Delta Sleep-Inducing Peptide) — benefits, dosing, side effects, research data, and where to buy.
| Property | AICAR | DSIP |
|---|---|---|
| Category | Performance | Performance |
| Full Name | 5-Aminoimidazole-4-carboxamide Ribonucleotide (Acadesine) | Delta Sleep-Inducing Peptide |
| Molecular Weight | 338.21 g/mol | 848.8 Da |
| Half-Life | ~2-3 hours | ~15-25 minutes |
| Amino Acids | Nucleoside analog | 9 |
| Typical Dose | — | 100-200 mcg |
| Route | — | SC / IV / Intranasal |
| Purity | >99% | — |
| Studies Count | 180 | 74 |
| Research Status | Active Research | Pre-clinical |
AICAR Benefits
- ✓Increases endurance capacity, enhances fatty acid oxidation, promotes mitochondrial biogenesis, improves glucose uptake, cardioprotective effects
DSIP Benefits
- ✓Promotes deep delta wave sleep
- ✓Normalizes disrupted sleep patterns
- ✓Reduces cortisol and stress response
- ✓Pain modulating effects
- ✓Antioxidant properties
AICAR Dosing
Research doses: 50-150 mg subcutaneously. Typically administered 30-60 minutes before physical activity in research settings.
DSIP Dosing
Standard: 100-200 mcg SC or IV, 30-60 min before bed|Cycle: 10-14 days, 5-7 days off|Chronic insomnia: 100 mcg daily for 2-3 weeks|Can be combined with Ipamorelin pre-bed
AICAR Side Effects
- ⚠Potential hypoglycemia, lactic acidosis at high doses, injection site reactions. Banned by WADA as a metabolic modulator.
DSIP Side Effects
- ⚠Common (Mild): Morning grogginess initially, mild headache
- ⚠Rare: Vivid dreams, temporary appetite changes
- ⚠Generally very well tolerated
Research Overview
AICAR
Salk Institute researchers demonstrated AICAR could increase endurance in sedentary mice by 44% without exercise training. Activates AMPK, triggering PGC-1α expression, mitochondrial biogenesis, and enhanced fatty acid β-oxidation.
DSIP
DSIP has moderate clinical evidence from European studies. Human trials show improved sleep quality and normalized sleep-wake cycles. Also studied for alcohol and opiate withdrawal. Unique mechanism distinct from traditional sleep aids.
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