Gamma-MSH vs Eyeseryl
Head-to-head comparison of Gamma-MSH (Gamma-Melanocyte-Stimulating Hormone) and Eyeseryl (Acetyl Tetrapeptide-5) — benefits, dosing, side effects, research data, and where to buy.
| Property | Gamma-MSH | Eyeseryl |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Gamma-Melanocyte-Stimulating Hormone | Acetyl Tetrapeptide-5 |
| Molecular Weight | N/A | 492.5 Da |
| Half-Life | Minutes | N/A |
| Amino Acids | 12 | 4 |
| Typical Dose | 10–500 nM | 0.5-2% in eye-area cosmetic products |
| Route | In vitro / ex vivo | Topical |
| Purity | ≥98% | ≥98% |
| Studies Count | 45 | 18 |
| Research Status | Pre-clinical | Clinical |
Gamma-MSH Benefits
- ✓Melanocortin signaling
- ✓Pigment-pathway research
- ✓May modulate melanocyte activity
- ✓Useful for UV-response studies
Eyeseryl Benefits
- ✓under-eye puffiness reduction
- ✓cosmetic firming support
- ✓appearance of dark circles
- ✓eye-area smoothing
Gamma-MSH Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Eyeseryl Dosing
Topical eye cream 0.5-2%|Apply 1-2x daily under eyes|Use gently on intact skin only
Gamma-MSH Side Effects
- ⚠Short peptide half-life
- ⚠Receptor promiscuity
- ⚠Limited metabolic stability
Eyeseryl Side Effects
- ⚠eye-area irritation
- ⚠dryness
- ⚠rare contact allergy
Research Overview
Gamma-MSH
Gamma-MSH has been investigated as part of the broader melanocortin network that regulates pigmentation. Evidence suggests it can contribute to melanocyte signaling, though its cosmetic use remains experimental.
Eyeseryl
Acetyl tetrapeptide-5 has topical cosmetic literature and formulation studies focused on edema reduction and eye-contour improvement. It is mainly used for appearance benefits rather than as a systemic therapeutic peptide.
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