FGF2 vs Palifermin
Head-to-head comparison of FGF2 (Recombinant Human Fibroblast Growth Factor 2) and Palifermin (Recombinant Human Keratinocyte Growth Factor (KGF, FGF7)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | FGF2 | Palifermin |
|---|---|---|
| Category | Recovery & Healing | Recovery & Healing |
| Full Name | Recombinant Human Fibroblast Growth Factor 2 | Recombinant Human Keratinocyte Growth Factor (KGF, FGF7) |
| Molecular Weight | 17.2 kDa | 16.3 kDa |
| Half-Life | minutes to <1 hour local | 4–6 hours |
| Amino Acids | 155 | 140 |
| Typical Dose | 1–10 µg/cm²/day | 60 µg/kg/day |
| Route | Topical | Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 1200 | 250 |
| Research Status | Clinical | Clinical |
FGF2 Benefits
- ✓angiogenesis
- ✓fibroblast proliferation
- ✓granulation tissue formation
- ✓accelerated re-epithelialization
Palifermin Benefits
- ✓epithelial protection
- ✓mucosal regeneration
- ✓barrier restoration
- ✓reduced inflammatory injury
FGF2 Dosing
Topical spray/gel daily|intralesional microdoses in studies|short cycles during active repair
Palifermin Dosing
IV 60 µg/kg/day for 3 days before and 3 days after insult|research protocols vary|short courses only
FGF2 Side Effects
- ⚠local swelling
- ⚠pain
- ⚠fibroblast overgrowth/scarring
- ⚠theoretical malignancy concern
Palifermin Side Effects
- ⚠rash
- ⚠taste changes
- ⚠edema
- ⚠arthralgia
Research Overview
FGF2
FGF2 has extensive preclinical and clinical literature for skin ulcers, burns, and postsurgical repair, largely through angiogenic and mesenchymal-cell signaling. It remains one of the most studied repair factors for improving tissue perfusion and remodeling.
Palifermin
Palifermin is clinically established for mucosal protection and has been studied for epithelial repair in other tissues. The strongest evidence is for epithelial resilience and regeneration rather than direct dermal remodeling.
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