Dolastatin 10 vs Mambalgin-1
Head-to-head comparison of Dolastatin 10 (Dolastatin 10) and Mambalgin-1 (Mambalgin-1 from Dendroaspis polylepis venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Dolastatin 10 | Mambalgin-1 |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Dolastatin 10 | Mambalgin-1 from Dendroaspis polylepis venom |
| Molecular Weight | 771.0 Da | 6,300 Da |
| Half-Life | N/A | Minutes to hours |
| Amino Acids | 5 | 57 |
| Typical Dose | N/A in humans; subnanomolar to low-nanomolar in vitro | 0.1-1 nmol intrathecal|10-100 nM in vitro|single-dose rodent studies |
| Route | Intravenous | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 300 | 55 |
| Research Status | Pre-clinical | Pre-clinical |
Dolastatin 10 Benefits
- ✓antineoplastic
- ✓microtubule disruption
- ✓antimitotic
- ✓ADC payload scaffold
Mambalgin-1 Benefits
- ✓ASIC channel inhibition
- ✓non-opioid analgesia research
- ✓sensory-neuron physiology
- ✓lead optimization for pain therapeutics
Dolastatin 10 Dosing
research-grade in vitro nanomolar use|early IV oncology exploration|no approved dosing regimen
Mambalgin-1 Dosing
Intrathecal pain-behavior studies|ASIC1a/ASIC1b electrophysiology|Acute dosing in rodents
Dolastatin 10 Side Effects
- ⚠peripheral neuropathy
- ⚠neutropenia
- ⚠fatigue
Mambalgin-1 Side Effects
- ⚠Hypoactivity at high dose
- ⚠off-target ASIC blockade
- ⚠local irritation
Research Overview
Dolastatin 10
Dolastatin 10 became famous for extreme cytotoxic potency and its ability to block tubulin polymerization. Although the native compound itself did not become a standard therapy, it inspired a major class of clinically important auristatin-based payloads.
Mambalgin-1
Pre-clinical work shows mambalgin-1 can reduce pain behaviors by modulating proton-gated ion channels in peripheral and central pathways. It has become an important template for developing ASIC-targeted analgesics.
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