Cholecystokinin-8 vs Oxyntomodulin
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Oxyntomodulin (Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Oxyntomodulin |
|---|---|---|
| Category | Endocrine Peptides | Weight Management |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide |
| Molecular Weight | 1143.2 Da | ~4,200 Da |
| Half-Life | 1-2 min | 12-15 minutes |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 37 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | Research doses vary; commonly 100-300 mcg in small human studies |
| Route | endogenous secretion|research IV/SC | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 80 |
| Research Status | Endogenous | Clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Oxyntomodulin Benefits
- ✓reduces appetite
- ✓increases satiety
- ✓supports weight loss
- ✓improves postprandial metabolic signaling
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Oxyntomodulin Dosing
Research-only dosing|Subcutaneous or IV administration in trials|Pair with calorie restriction and monitoring
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Oxyntomodulin Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠decreased appetite beyond target
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Oxyntomodulin
Human studies showed acute reductions in food intake and modest weight loss, helping establish the GLP-1 and glucagon co-agonism concept. It remains a foundational peptide for obesity and satiety research.
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