Cholecystokinin-8 vs Mazdutide
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Mazdutide (IBI362, long-acting GLP-1 receptor and glucagon receptor dual agonist) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Mazdutide |
|---|---|---|
| Category | Endocrine Peptides | Weight Management |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | IBI362, long-acting GLP-1 receptor and glucagon receptor dual agonist |
| Molecular Weight | 1143.2 Da | ~5,000 Da |
| Half-Life | 1-2 min | 5-7 days |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 37 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 1-6 mg weekly in obesity trials |
| Route | endogenous secretion|research IV/SC | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 28 |
| Research Status | Endogenous | Clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Mazdutide Benefits
- ✓clinically meaningful weight loss
- ✓better glycemic control
- ✓reduced waist circumference
- ✓improved lipid profile
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Mazdutide Dosing
Once-weekly SC titration|Dose escalation every 4 weeks|Use with lifestyle modification
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Mazdutide Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠constipation
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Mazdutide
Clinical programs have shown substantial reductions in body weight and improvements in cardiometabolic risk markers. It is a prominent newer dual agonist in the obesity literature.
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