Cholecystokinin-8 vs Neuropeptide S
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Neuropeptide S (Neuropeptide S) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Neuropeptide S |
|---|---|---|
| Category | Endocrine Peptides | Cognitive Enhancement |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Neuropeptide S |
| Molecular Weight | 1143.2 Da | 2203 Da |
| Half-Life | 1-2 min | Minutes to <1 hour |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 20 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | Research-only; no validated human dose |
| Route | endogenous secretion|research IV/SC | Intracerebroventricular/Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 28 |
| Research Status | Endogenous | Pre-clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
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