Cholecystokinin-8 vs GPE
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and GPE (Glycyl-L-prolyl-L-glutamic acid) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | GPE |
|---|---|---|
| Category | Endocrine Peptides | Cognitive Enhancement |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Glycyl-L-prolyl-L-glutamic acid |
| Molecular Weight | 1143.2 Da | 301.30 Da |
| Half-Life | 1-2 min | minutes |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 3 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 0.1-10 mg/kg preclinical |
| Route | endogenous secretion|research IV/SC | Intranasal/Intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 25 |
| Research Status | Endogenous | Pre-clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
GPE Benefits
- ✓memory consolidation
- ✓neuroprotection
- ✓synaptic plasticity
- ✓learning support
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
GPE Dosing
intranasal or ICV research doses|0.1-10 mg/kg preclinical range|repeat daily or intermittent protocols
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
GPE Side Effects
- ⚠limited human safety data
- ⚠short half-life
- ⚠local irritation with nasal delivery
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
GPE
Preclinical studies suggest GPE can reduce neuronal damage and support plasticity-related pathways in the brain. Research interest centers on hippocampal function, which links it to learning and memory paradigms.
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