Cholecystokinin-8 vs NGF
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and NGF (Beta-Nerve Growth Factor (human NGF beta)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | NGF |
|---|---|---|
| Category | Endocrine Peptides | Cognitive Enhancement |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Beta-Nerve Growth Factor (human NGF beta) |
| Molecular Weight | 1143.2 Da | 13,600 Da |
| Half-Life | 1-2 min | hours |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 118 aa |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | research-only microgram range |
| Route | endogenous secretion|research IV/SC | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 3500 |
| Research Status | Endogenous | Pre-clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
NGF Benefits
- ✓neurite outgrowth
- ✓cholinergic support
- ✓nerve repair
- ✓neuroprotection
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
NGF Dosing
0.01-1 µg/kg in experimental delivery studies|local CNS or intranasal research delivery|single or repeated low-dose protocols
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
NGF Side Effects
- ⚠pain at injection site
- ⚠hyperalgesia
- ⚠autonomic effects
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
NGF
NGF is one of the most established growth factors in neurobiology and has been investigated for both central and peripheral neuronal repair. Its strongest cognitive relevance comes from supporting basal forebrain cholinergic neurons and downstream memory circuitry.
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