Cholecystokinin-8 vs FS315
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and FS315 (Follistatin-315 (FS315)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | FS315 |
|---|---|---|
| Category | Endocrine Peptides | Muscle & Performance |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Follistatin-315 (FS315) |
| Molecular Weight | 1143.2 Da | ~40 kDa |
| Half-Life | 1-2 min | N/A; depends on construct/delivery |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 315 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | Research-only; no standardized human dose |
| Route | endogenous secretion|research IV/SC | Intramuscular / research expression systems |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 95 |
| Research Status | Endogenous | Pre-clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
FS315 Benefits
- ✓activin neutralization
- ✓muscle growth signaling
- ✓anti-catabolic support
- ✓tissue repair modulation
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
FS315 Dosing
Research-only recombinant/protein-expression studies|no standardized clinical dose|route varies by platform
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
FS315 Side Effects
- ⚠off-target endocrine effects
- ⚠immune response risk
- ⚠fluid balance changes
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
FS315
Follistatin-315 is a key reference isoform in studies of muscle anabolism and reproductive/endocrine biology. In muscle research, it is relevant because it suppresses activin and can indirectly blunt myostatin pathway output.
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