Cholecystokinin-8 vs Elamipretide
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Elamipretide (Elamipretide (MTP-131, SS-31)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Elamipretide |
|---|---|---|
| Category | Endocrine Peptides | Muscle & Performance |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Elamipretide (MTP-131, SS-31) |
| Molecular Weight | 1143.2 Da | 639.8 Da |
| Half-Life | 1-2 min | 1-4 hours |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 4 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 0.01-0.25 mg/kg/day |
| Route | endogenous secretion|research IV/SC | Subcutaneous/Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 120 |
| Research Status | Endogenous | Clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Elamipretide Benefits
- ✓mitochondrial protection
- ✓reduced oxidative stress
- ✓improved fatigue resistance
- ✓may support exercise tolerance
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Elamipretide Dosing
0.01-0.25 mg/kg/day SC (clinical research)|daily dosing in trials|alternative IV protocols in some studies
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Elamipretide Side Effects
- ⚠nausea
- ⚠injection-site reactions
- ⚠diarrhea
- ⚠headache
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Elamipretide
Clinical and translational studies show elamipretide can improve mitochondrial function and some functional endpoints in mitochondrial disorders. Skeletal muscle research suggests benefits are driven by energy metabolism rather than direct muscle-building effects.
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