Cholecystokinin-8 vs Anamorelin
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Anamorelin (Anamorelin hydrochloride (ONO-7643)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Anamorelin |
|---|---|---|
| Category | Endocrine Peptides | Growth Hormone |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Anamorelin hydrochloride (ONO-7643) |
| Molecular Weight | 1143.2 Da | N/A |
| Half-Life | 1-2 min | about 9 hours |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | N/A |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 50 mg/day |
| Route | endogenous secretion|research IV/SC | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 95 |
| Research Status | Endogenous | Clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Anamorelin Benefits
- ✓stimulates appetite
- ✓raises IGF-1
- ✓may support weight gain
- ✓oral dosing
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Anamorelin Dosing
50 mg orally once daily|often studied with food or per protocol|track weight, appetite, and glucose markers
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Anamorelin Side Effects
- ⚠hyperglycemia
- ⚠peripheral edema
- ⚠constipation or nausea
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Anamorelin
Trials in cachexia populations showed increased appetite and modest gains in body weight and IGF-1. Regulatory progress has varied by region, but it remains a well-studied ghrelin agonist in the GH space.
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