C-peptide vs FS315

Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and FS315 (Follistatin-315 (FS315)) — benefits, dosing, side effects, research data, and where to buy.

Research Score

PropertyC-peptideFS315
CategoryPain ManagementMuscle & Performance
Full NameConnecting peptide (C-peptide)Follistatin-315 (FS315)
Molecular Weight3020.3 Da~40 kDa
Half-Life~20-30 minN/A; depends on construct/delivery
Amino Acids31315
Typical Doseno approved analgesic dose|research-onlyResearch-only; no standardized human dose
RouteIV|subQIntramuscular / research expression systems
Purity≥98%≥98%
Studies Count4695
Research StatusPre-clinicalPre-clinical

C-peptide Benefits

  • diabetic neuropathy research
  • nerve function support
  • possible analgesic effect

FS315 Benefits

  • activin neutralization
  • muscle growth signaling
  • anti-catabolic support
  • tissue repair modulation

C-peptide Dosing

0.5-1.0 mg/day in research|route varies by protocol

FS315 Dosing

Research-only recombinant/protein-expression studies|no standardized clinical dose|route varies by platform

C-peptide Side Effects

  • injection-site reactions
  • unknown long-term safety

FS315 Side Effects

  • off-target endocrine effects
  • immune response risk
  • fluid balance changes

Research Overview

C-peptide

C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.

FS315

Follistatin-315 is a key reference isoform in studies of muscle anabolism and reproductive/endocrine biology. In muscle research, it is relevant because it suppresses activin and can indirectly blunt myostatin pathway output.

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Common Stacking Partners

C-peptide stacks with:

C-peptideConnecting peptide

FS315 stacks with:

CreatineVitamin DLeucine
neuropathic-paindiabetic-neuropathynerve-repairfollistatinactivin-inhibitormyostatin-pathwayprotein