Beta-MSH vs Eyeseryl
Head-to-head comparison of Beta-MSH (Beta-Melanocyte-Stimulating Hormone) and Eyeseryl (Acetyl Tetrapeptide-5) — benefits, dosing, side effects, research data, and where to buy.
| Property | Beta-MSH | Eyeseryl |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Beta-Melanocyte-Stimulating Hormone | Acetyl Tetrapeptide-5 |
| Molecular Weight | N/A | 492.5 Da |
| Half-Life | Minutes | N/A |
| Amino Acids | 18 | 4 |
| Typical Dose | 10–500 nM | 0.5-2% in eye-area cosmetic products |
| Route | In vitro / ex vivo | Topical |
| Purity | ≥98% | ≥98% |
| Studies Count | 80 | 18 |
| Research Status | Pre-clinical | Clinical |
Beta-MSH Benefits
- ✓Promotes melanogenesis
- ✓Supports melanocyte dendricity
- ✓Useful in pigmentation pathway mapping
- ✓May increase eumelanin bias
Eyeseryl Benefits
- ✓under-eye puffiness reduction
- ✓cosmetic firming support
- ✓appearance of dark circles
- ✓eye-area smoothing
Beta-MSH Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Eyeseryl Dosing
Topical eye cream 0.5-2%|Apply 1-2x daily under eyes|Use gently on intact skin only
Beta-MSH Side Effects
- ⚠Short peptide half-life
- ⚠Receptor cross-talk
- ⚠Limited plasma stability
Eyeseryl Side Effects
- ⚠eye-area irritation
- ⚠dryness
- ⚠rare contact allergy
Research Overview
Beta-MSH
Beta-MSH is one of the endogenous melanocortin peptides studied for its ability to influence melanin synthesis. Most evidence is mechanistic, focusing on receptor signaling and melanocyte biology rather than cosmetic use.
Eyeseryl
Acetyl tetrapeptide-5 has topical cosmetic literature and formulation studies focused on edema reduction and eye-contour improvement. It is mainly used for appearance benefits rather than as a systemic therapeutic peptide.
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