5-Amino-1MQ vs Cholecystokinin-8
Head-to-head comparison of 5-Amino-1MQ (5-Amino-1-methylquinolinium) and Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | 5-Amino-1MQ | Cholecystokinin-8 |
|---|---|---|
| Category | Weight Management | Endocrine Peptides |
| Full Name | 5-Amino-1-methylquinolinium | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) |
| Molecular Weight | 178.23 g/mol | 1143.2 Da |
| Half-Life | ~6 hours | 1-2 min |
| Amino Acids | Small molecule | DY(SO3H)MGWMDF-NH2 |
| Typical Dose | — | physiologic low-picomolar-nanomolar range|research-dependent |
| Route | — | endogenous secretion|research IV/SC |
| Purity | >98% | ≥98% |
| Studies Count | 28 | 97 |
| Research Status | Active Research | Endogenous |
5-Amino-1MQ Benefits
- ✓Reduces body fat without appetite changes, lowers cholesterol, increases NAD+ levels, improves metabolic efficiency, supports cellular energy production
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
5-Amino-1MQ Dosing
Research doses: 50-150 mg orally daily. Often cycled 8-12 weeks on, 4 weeks off. Best taken in the morning.
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
5-Amino-1MQ Side Effects
- ⚠Generally well-tolerated in preclinical models. Potential mild GI discomfort and headache. Long-term human safety data is limited.
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Research Overview
5-Amino-1MQ
Studies in diet-induced obese mice showed significant reductions in body weight, white adipose tissue mass, and cholesterol levels without changes in food intake. Works by inhibiting NNMT enzyme to increase NAD+ and activate sirtuins.
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
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