Vasoactive Intestinal Peptide
VIP (Vasoactive Intestinal Peptide)
28 Amino Acids · MW: 3,326.82 Da
Amino Acids
28
Molecular Weight
3,326.82 Da
Half-life
~1-2 minutes (plasma)
Research Score
4.3
Studies
300
Storage
-20°C lyophilized, 2-8°C reconstituted
What is Vasoactive Intestinal Peptide?
VIP is a 28-amino acid neuropeptide found throughout the body. It regulates smooth muscle activity, epithelial cell secretion, and blood flow. In recent years, it has gained attention for treating chronic inflammatory response syndrome (CIRS), mold illness, and neuroinflammation.
Key Benefits & Mechanisms
Regulates inflammatory cytokines
Treats CIRS and mold illness
Pulmonary artery vasodilation
Neuroprotective properties
Improves cognitive function in CIRS
Regulates TGF-beta and MMP-9
Supports gut function
Research Summary
VIP has moderate-to-strong preclinical and growing clinical evidence, with over 300 studies supporting its immunomodulatory and neuroprotective properties. Mechanistically, it binds the VPAC1/VPAC2 receptors to suppress pro-inflammatory cytokines (TNF-α, IL-6, IL-12), promote the anti-inflammatory cytokine IL-10, inhibit NF-κB signaling, modulate Th1/Th2 balance, and expand regulatory T cells. Clinically, the Dr. Ritchie Shoemaker intranasal protocol for chronic inflammatory response syndrome (CIRS)/mold illness is widely used in functional medicine, where VIP has demonstrated anti-inflammatory and neuroprotective effects and growing acceptance.
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