Tirzepatide

GIP/GLP-1 Dual Receptor Agonist

39 Amino Acids · MW: 4,813.45 Da

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Amino Acids

Molecular Weight

4,813.45 Da

Half-life

~5 days

Research Score

4.8

Studies

890

Storage

N/A

What is Tirzepatide?

Tirzepatide is a first-in-class dual GIP and GLP-1 receptor agonist. FDA-approved as Mounjaro (diabetes) and Zepbound (weight management). It offers superior weight loss compared to GLP-1-only agonists by targeting two incretin pathways simultaneously.

Key Benefits & Mechanisms

Superior weight loss (up to 22% body weight)

Dual incretin pathway activation

Excellent glycemic control

Reduced cardiovascular risk markers

Improved insulin sensitivity

Significant HbA1c reduction

Reduced appetite and food intake

Research Summary

Tirzepatide clinical trials (SURMOUNT, SURPASS) show it outperforms semaglutide in head-to-head comparisons for weight loss. The dual agonist mechanism provides additive metabolic benefits.

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