Mechano Growth Factor
IGF-1Ec Splice Variant
24 Amino Acids · MW: 2,867 Da
Amino Acids
24
Molecular Weight
2,867 Da
Half-life
~5-7 minutes
Research Score
4.0
Studies
78
Storage
N/A
What is Mechano Growth Factor?
MGF (Mechano Growth Factor) is a splice variant of IGF-1 produced in response to mechanical overload of skeletal muscle. It activates satellite cells to initiate muscle repair and new fiber formation. The native form has a very short half-life, which is why PEG-MGF was developed.
Key Benefits & Mechanisms
Activates muscle satellite cells
Promotes local muscle repair
Natural response to exercise
Initiates muscle hyperplasia
Enhances recovery from mechanical stress
Short-acting for precise local effects
Complements systemic IGF-1
Research Summary
MGF has strong pre-clinical evidence for its role in muscle repair following mechanical damage. Well-characterized as a natural splice variant of IGF-1. The short half-life limits practical applications, leading to development of PEG-MGF. Important in understanding exercise-induced muscle adaptation.
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