Metreleptin
Recombinant Human Leptin
146 aa Amino Acids · MW: Approximately 16,000 Da
Amino Acids
146 aa
Molecular Weight
Approximately 16,000 Da
Half-life
Approximately 3-5 hours
Research Score
4.1
Studies
160
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Metreleptin?
Metreleptin is a recombinant leptin replacement therapy used mainly for leptin deficiency and generalized lipodystrophy. In weight-management research it acts through hypothalamic energy-balance signaling rather than direct lipolysis.
Key Benefits & Mechanisms
appetite regulation
improved energy balance
reduced ectopic fat
better metabolic control
Research Summary
Metreleptin has robust evidence in congenital or acquired leptin-deficient states, where it improves hyperphagia and metabolic parameters. In common obesity it has limited efficacy, but it remains important for mechanistic and rare-disease weight-management research.
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