Palmitoyl Pentapeptide-4
Matrixyl (Palmitoyl Pentapeptide-4)
5 Amino Acids · MW: 802.05 Da
Amino Acids
5
Molecular Weight
802.05 Da
Half-life
N/A (topical)
Research Score
4.5
Studies
89
Storage
N/A
What is Palmitoyl Pentapeptide-4?
Matrixyl (Palmitoyl Pentapeptide-4) is one of the most well-studied and commercially successful anti-aging peptides. It stimulates collagen I, III, and IV production, as well as fibronectin synthesis. Clinical studies show it can reduce wrinkle depth comparable to retinol but without irritation.
Key Benefits & Mechanisms
Stimulates collagen I, III, and IV synthesis
Reduces wrinkle depth and volume
Comparable to retinol without irritation
Improves skin firmness and elasticity
Promotes fibronectin production
Well-tolerated by sensitive skin
Proven clinical efficacy
Research Summary
Matrixyl has strong clinical evidence for anti-aging applications. Double-blind studies demonstrate significant wrinkle reduction. One of the most commercially successful and well-validated cosmetic peptides. Extensive safety data from widespread consumer use.
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