LEU-ENK
Leucine Enkephalin
YGGFL Amino Acids · MW: 555.63
Amino Acids
YGGFL
Molecular Weight
555.63
Half-life
seconds to minutes
Research Score
4.6
Studies
86
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is LEU-ENK?
An endogenous pentapeptide from the proenkephalin family that acts on opioid receptors. It is a classic opioid neuropeptide used in analgesia and receptor-binding studies.
Key Benefits & Mechanisms
analgesia research
opioid receptor binding
stress modulation
Research Summary
Leucine enkephalin is a well-documented endogenous opioid peptide with rapid breakdown by peptidases. It is routinely used as a benchmark ligand in opioid receptor assays and neurochemical studies.
Related Peptides
Neurokinin A
Neurokinin A
A tachykinin neuropeptide generated from the preprotachykinin A precursor. It participates in pain transmission, neurogenic inflammation, and smooth muscle signaling.
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Oxytocin
A hypothalamic nonapeptide neuropeptide and hormone best known for roles in parturition, lactation, and social behavior. It is also used as a reference compound in receptor and intranasal-delivery research.
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Substance P
A tachykinin neuropeptide involved in nociception, inflammation, and gastrointestinal signaling. It is widely used in receptor pharmacology and pain-pathway research.
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Methionine Enkephalin
An endogenous pentapeptide closely related to leucine enkephalin and derived from proenkephalin. It is studied for opioid receptor activity, pain modulation, and neuroimmune signaling.
Neuropeptides