Leptin
Recombinant Human Leptin
146 aa Amino Acids · MW: 16000 Da
Amino Acids
146 aa
Molecular Weight
16000 Da
Half-life
2-4 hours
Research Score
4.6
Studies
800
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Leptin?
Leptin is an adipocyte-derived hormone that signals energy sufficiency to the hypothalamus and suppresses appetite. In research, it is most effective in congenital leptin deficiency or hypoleptinemic states rather than common obesity.
Key Benefits & Mechanisms
appetite suppression
improved satiety signaling
reduced meal size
energy homeostasis support
Research Summary
Leptin has extensive literature supporting its role in appetite regulation, body-fat signaling, and reproductive-metabolic adaptation. Clinical benefit is strongest in rare leptin-deficient syndromes, while most common obesity states show leptin resistance.
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MEDI0382, long-acting GLP-1 and glucagon receptor dual agonist
Cotadutide is a synthetic oxyntomodulin analogue designed to engage both GLP-1 and glucagon receptors. It was developed to improve weight loss and metabolic markers in obesity and type 2 diabetes research.
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Weight Management