KTTKS
L-Lysyl-L-threonyl-L-threonyl-L-lysyl-L-serine (type I collagen-derived pentapeptide)
5 Amino Acids · MW: 563.65 Da
Amino Acids
5
Molecular Weight
563.65 Da
Half-life
Minutes; short in topical formulations
Research Score
4.0
Studies
120
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is KTTKS?
A cosmetic signal peptide fragment derived from type I collagen that is studied for supporting dermal matrix production. It is relevant to anti-aging and scar-reduction formulations because it may help stimulate fibroblast activity and collagen synthesis.
Key Benefits & Mechanisms
collagen-support
fine-line-reduction
fibroblast-activation
dermal-firmness
Research Summary
KTTKS has been studied in skin-cell and skin-explant models as a collagen-mimetic peptide that can influence extracellular matrix signaling. The peptide is widely referenced in cosmetic science, although the palmitoylated versions are more common in commercial formulations.
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