Cycloviolacin O1
Cycloviolacin O1 cyclotide
29 Amino Acids · MW: ≈3.1 kDa
Amino Acids
29
Molecular Weight
≈3.1 kDa
Half-life
Not established; unusually protease-resistant
Research Score
4.4
Studies
89
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Cycloviolacin O1?
A 29-residue cyclotide from Viola odorata with a Möbius-type cyclic cystine-knot topology. It shows membrane-active bioactivity and has been explored as an anticancer and antimicrobial lead.
Key Benefits & Mechanisms
anticancer lead
antimicrobial
membrane-active scaffold
Research Summary
A well-studied Viola odorata cyclotide that helped establish the potency of plant cyclotides against microbial and mammalian membranes. It is frequently used as a lead peptide for anticancer and membrane-biology research.
Related Peptides
Kalata B1
Kalata B1 cyclotide
A 29-residue cyclotide from Oldenlandia affinis with a cyclic cystine-knot fold. It is the prototypical plant cyclotide, known for strong membrane binding and high protease resistance.
Plant-DerivedKalata B2
Kalata B2 cyclotide
A 29-residue cyclotide from Oldenlandia affinis with the same cyclic cystine-knot family fold as kalata B1. It is a common model for studying cyclotide stability, folding, and bioactivity.
Plant-DerivedCycloviolacin O2
Cycloviolacin O2 cyclotide
A 29-residue cyclotide from Viola odorata with a compact cyclic cystine-knot fold. It is one of the best-known plant cyclotides for strong cytotoxic and antimicrobial activity.
Plant-DerivedCirculin A
Circulin A cyclotide
A plant cyclotide from Chassalia parviflora with a highly constrained cyclic cystine-knot fold. It has been reported as an antiviral lead, including anti-HIV activity in screening studies.
Plant-Derived