CCK-8S
Cholecystokinin Octapeptide, Sulfated
8 aa Amino Acids · MW: 1143 Da
Amino Acids
8 aa
Molecular Weight
1143 Da
Half-life
minutes
Research Score
4.1
Studies
300
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is CCK-8S?
CCK-8S is the bioactive octapeptide form of cholecystokinin and a classic short-term satiety signal. It reduces meal size and slows gastric emptying in experimental models and human challenge studies.
Key Benefits & Mechanisms
early satiety
reduced meal size
slower gastric emptying
short-term appetite suppression
Research Summary
CCK has long been used to study satiety, feeding termination, and gut-brain signaling. The sulfated octapeptide is especially important because it represents the active form commonly discussed in appetite research.
Related Peptides
Oxyntomodulin
Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide
Oxyntomodulin is a naturally occurring proglucagon-derived peptide that activates GLP-1 and glucagon pathways. It is a key research tool for appetite suppression and energy balance studies in obesity.
Weight ManagementCotadutide
MEDI0382, long-acting GLP-1 and glucagon receptor dual agonist
Cotadutide is a synthetic oxyntomodulin analogue designed to engage both GLP-1 and glucagon receptors. It was developed to improve weight loss and metabolic markers in obesity and type 2 diabetes research.
Weight ManagementMazdutide
IBI362, long-acting GLP-1 receptor and glucagon receptor dual agonist
Mazdutide is a long-acting oxyntomodulin-inspired dual agonist being developed for obesity and metabolic disease. It is designed to drive clinically meaningful weight loss while improving glucose and lipid parameters.
Weight ManagementDulaglutide
Recombinant GLP-1 receptor agonist Fc fusion protein
Dulaglutide is a long-acting GLP-1 receptor agonist used primarily in type 2 diabetes. It consistently produces modest weight loss and is widely studied as a benchmark incretin mimetic.
Weight Management