Tesofensine vs IGF-1 DES
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and IGF-1 DES (Des(1-3) Insulin-like Growth Factor 1) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | IGF-1 DES |
|---|---|---|
| Category | Weight Management | Growth Hormone |
| Full Name | Tesofensine (NS2330) | Des(1-3) Insulin-like Growth Factor 1 |
| Molecular Weight | 426.52 g/mol | 7365 Da |
| Half-Life | ~200-300 hours | ~20-30 minutes |
| Amino Acids | Small molecule | 67 |
| Typical Dose | — | — |
| Route | — | — |
| Purity | >98% | >98% |
| Studies Count | 35 | 65 |
| Research Status | Phase III Clinical Trials | Active Research |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
IGF-1 DES Benefits
- ✓Highly potent localized muscle growth, enhanced protein synthesis, satellite cell proliferation, does not bind to IGFBPs, rapid onset
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
IGF-1 DES Dosing
50-150 mcg per injection site bilaterally post-workout. 4-6 week cycles due to potency. Multiple daily injections in research.
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
IGF-1 DES Side Effects
- ⚠Hypoglycemia (dose-dependent), localized swelling, shorter duration limits systemic exposure compared to IGF-1 LR3.
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
IGF-1 DES
Missing first three amino acids (Gly-Pro-Glu) eliminates IGFBP binding, resulting in 100% bioavailable IGF-1R stimulation. Activates PI3K/Akt/mTOR for protein synthesis and satellite cell proliferation.
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