Tesofensine vs AICAR
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and AICAR (5-Aminoimidazole-4-carboxamide Ribonucleotide (Acadesine)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | AICAR |
|---|---|---|
| Category | Weight Management | Performance |
| Full Name | Tesofensine (NS2330) | 5-Aminoimidazole-4-carboxamide Ribonucleotide (Acadesine) |
| Molecular Weight | 426.52 g/mol | 338.21 g/mol |
| Half-Life | ~200-300 hours | ~2-3 hours |
| Amino Acids | Small molecule | Nucleoside analog |
| Typical Dose | — | — |
| Route | — | — |
| Purity | >98% | >99% |
| Studies Count | 35 | 180 |
| Research Status | Phase III Clinical Trials | Active Research |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
AICAR Benefits
- ✓Increases endurance capacity, enhances fatty acid oxidation, promotes mitochondrial biogenesis, improves glucose uptake, cardioprotective effects
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
AICAR Dosing
Research doses: 50-150 mg subcutaneously. Typically administered 30-60 minutes before physical activity in research settings.
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
AICAR Side Effects
- ⚠Potential hypoglycemia, lactic acidosis at high doses, injection site reactions. Banned by WADA as a metabolic modulator.
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
AICAR
Salk Institute researchers demonstrated AICAR could increase endurance in sedentary mice by 44% without exercise training. Activates AMPK, triggering PGC-1α expression, mitochondrial biogenesis, and enhanced fatty acid β-oxidation.
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