Somatropin vs Macimorelin
Head-to-head comparison of Somatropin (Recombinant human growth hormone (rhGH)) and Macimorelin (Macimorelin acetate (AEZS-130)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Somatropin | Macimorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Recombinant human growth hormone (rhGH) | Macimorelin acetate (AEZS-130) |
| Molecular Weight | 22125 Da | N/A |
| Half-Life | 2-4 hours | about 4-6 hours |
| Amino Acids | 191 | N/A |
| Typical Dose | 0.004-0.03 mg/kg/day | 0.5 mg/kg single oral dose |
| Route | Subcutaneous | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 2000 | 120 |
| Research Status | Clinical/Approved | Clinical |
Somatropin Benefits
- ✓linear growth support
- ✓lean mass preservation
- ✓bone mineral accrual
- ✓IGF-1 elevation
Macimorelin Benefits
- ✓diagnostic GH stimulation
- ✓single oral dose
- ✓rapid measurable GH response
- ✓high clinical utility
Somatropin Dosing
daily subcutaneous dosing|titrate to IGF-1 and response|weight-based replacement protocols
Macimorelin Dosing
0.5 mg/kg orally as a single dose|fasted testing conditions|serial GH sampling after administration
Somatropin Side Effects
- ⚠edema
- ⚠arthralgia
- ⚠insulin resistance
Macimorelin Side Effects
- ⚠dysgeusia or taste disturbance
- ⚠nausea
- ⚠headache
Research Overview
Somatropin
Somatropin is the best-studied growth hormone peptide, with decades of clinical use in pediatric and adult GH deficiency. Trials consistently show increases in IGF-1 and growth velocity, with adverse effects mainly reflecting excessive GH exposure.
Macimorelin
Macimorelin has been validated in clinical testing as an oral alternative to injectable GH stimulation tests. Its short-term use makes it a useful translational tool for evaluating pituitary GH reserve.
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