Secretin vs Oxyntomodulin
Head-to-head comparison of Secretin (Human Secretin) and Oxyntomodulin (Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Secretin | Oxyntomodulin |
|---|---|---|
| Category | Gastrointestinal | Weight Management |
| Full Name | Human Secretin | Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide |
| Molecular Weight | 3055.4 Da | ~4,200 Da |
| Half-Life | 5-7 minutes | 12-15 minutes |
| Amino Acids | 27 | 37 |
| Typical Dose | 0.2 mcg/kg IV | Research doses vary; commonly 100-300 mcg in small human studies |
| Route | Intravenous | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 80 |
| Research Status | Clinical | Clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Oxyntomodulin Benefits
- ✓reduces appetite
- ✓increases satiety
- ✓supports weight loss
- ✓improves postprandial metabolic signaling
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Oxyntomodulin Dosing
Research-only dosing|Subcutaneous or IV administration in trials|Pair with calorie restriction and monitoring
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Oxyntomodulin Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠decreased appetite beyond target
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
Oxyntomodulin
Human studies showed acute reductions in food intake and modest weight loss, helping establish the GLP-1 and glucagon co-agonism concept. It remains a foundational peptide for obesity and satiety research.
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