Secretin vs Mazdutide
Head-to-head comparison of Secretin (Human Secretin) and Mazdutide (IBI362, long-acting GLP-1 receptor and glucagon receptor dual agonist) — benefits, dosing, side effects, research data, and where to buy.
| Property | Secretin | Mazdutide |
|---|---|---|
| Category | Gastrointestinal | Weight Management |
| Full Name | Human Secretin | IBI362, long-acting GLP-1 receptor and glucagon receptor dual agonist |
| Molecular Weight | 3055.4 Da | ~5,000 Da |
| Half-Life | 5-7 minutes | 5-7 days |
| Amino Acids | 27 | 37 |
| Typical Dose | 0.2 mcg/kg IV | 1-6 mg weekly in obesity trials |
| Route | Intravenous | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 28 |
| Research Status | Clinical | Clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Mazdutide Benefits
- ✓clinically meaningful weight loss
- ✓better glycemic control
- ✓reduced waist circumference
- ✓improved lipid profile
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Mazdutide Dosing
Once-weekly SC titration|Dose escalation every 4 weeks|Use with lifestyle modification
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Mazdutide Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠constipation
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
Mazdutide
Clinical programs have shown substantial reductions in body weight and improvements in cardiometabolic risk markers. It is a prominent newer dual agonist in the obesity literature.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.