Secretin vs NPY
Head-to-head comparison of Secretin (Human Secretin) and NPY (Neuropeptide Y) — benefits, dosing, side effects, research data, and where to buy.
| Property | Secretin | NPY |
|---|---|---|
| Category | Gastrointestinal | Cognitive Enhancement |
| Full Name | Human Secretin | Neuropeptide Y |
| Molecular Weight | 3055.4 Da | 4272 Da |
| Half-Life | 5-7 minutes | minutes |
| Amino Acids | 27 | 36 aa |
| Typical Dose | 0.2 mcg/kg IV | 1-10 µg preclinical range |
| Route | Intravenous | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 900 |
| Research Status | Clinical | Pre-clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
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