rhPDGF-BB vs FGF2
Head-to-head comparison of rhPDGF-BB (Recombinant Human Platelet-Derived Growth Factor-BB) and FGF2 (Recombinant Human Fibroblast Growth Factor 2) — benefits, dosing, side effects, research data, and where to buy.
| Property | rhPDGF-BB | FGF2 |
|---|---|---|
| Category | Recovery & Healing | Recovery & Healing |
| Full Name | Recombinant Human Platelet-Derived Growth Factor-BB | Recombinant Human Fibroblast Growth Factor 2 |
| Molecular Weight | 24.8 kDa | 17.2 kDa |
| Half-Life | minutes | minutes to <1 hour local |
| Amino Acids | 109 per chain (homodimer) | 155 |
| Typical Dose | 100 µg/g gel once daily | 1–10 µg/cm²/day |
| Route | Topical | Topical |
| Purity | ≥98% | ≥98% |
| Studies Count | 400 | 1200 |
| Research Status | Clinical | Clinical |
rhPDGF-BB Benefits
- ✓cell migration
- ✓fibroblast proliferation
- ✓collagen deposition
- ✓diabetic ulcer healing
FGF2 Benefits
- ✓angiogenesis
- ✓fibroblast proliferation
- ✓granulation tissue formation
- ✓accelerated re-epithelialization
rhPDGF-BB Dosing
Topical once daily|apply to clean wound bed|continue until complete granulation/closure
FGF2 Dosing
Topical spray/gel daily|intralesional microdoses in studies|short cycles during active repair
rhPDGF-BB Side Effects
- ⚠local erythema
- ⚠pain
- ⚠edema
- ⚠theoretical tumor-promoting risk
FGF2 Side Effects
- ⚠local swelling
- ⚠pain
- ⚠fibroblast overgrowth/scarring
- ⚠theoretical malignancy concern
Research Overview
rhPDGF-BB
rhPDGF-BB has one of the strongest clinical wound-healing datasets among growth factors and is best known for chronic diabetic foot ulcers. Its efficacy is tied to chemotaxis and mitogenesis in fibroblasts, smooth muscle cells, and macrophage-lineage cells.
FGF2
FGF2 has extensive preclinical and clinical literature for skin ulcers, burns, and postsurgical repair, largely through angiogenic and mesenchymal-cell signaling. It remains one of the most studied repair factors for improving tissue perfusion and remodeling.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.